Maternal viral infection and schizophrenia

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Maternal infection during pregnancy and schizophrenia.

For the 2007–2008 season, the Canadian National Advisory Committee on Immunization has for the first time recommended that all pregnant women be vaccinated against influenza. In the United States, the Centers for Disease Control and Prevention have recommended influenza vaccination for pregnant women in the second and third trimester of pregnancy since 1997; in 2004, this recommendation was rev...

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Maternal infection and schizophrenia: implications for prevention.

Accumulating evidence suggests that maternal infection is a risk factor for schizophrenia. Prospective epidemiological studies indicate that maternal influenza, toxoplasmosis, and genital/reproductive infection are associated with this disorder in offspring. Preclinical models of maternal immune activation have supported the neurobiological plausibility of these microbes in schizophrenia. Previ...

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Acute Hepatitis E Viral Infection in Pregnancy and Maternal Morbidity.

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Maternal influenza viral infection causes schizophrenia-like alterations of 5-HT₂A and mGlu₂ receptors in the adult offspring.

Epidemiological studies indicate that maternal influenza viral infection increases the risk for schizophrenia in the adult offspring. The serotonin and glutamate systems are suspected in the etiology of schizophrenia, as well as in the mechanism of action of antipsychotic drugs. The effects of hallucinogens, such as psilocybin and mescaline, require the serotonin 5-HT(2A) receptor, and induce s...

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ژورنال

عنوان ژورنال: British Journal of Psychiatry

سال: 1992

ISSN: 0007-1250,1472-1465

DOI: 10.1192/s0007125000139200